研究资料

本页面旨在为读者提供关于天然健康产品（NHP）与相关研究的基础资料。所有信息均来自公开发表的研究与监管机构的文件，仅供教育与参考之用。

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1) Phase II Study in Women with Persistent High-Risk HPV

Design: Prospective phase II; oral AHCC 3 g/day.
Key points: Many participants with long-standing high-risk HPV converted to HPV-negative during supplementation; regimen was well tolerated. Authors emphasize that the duration beyond the first negative test needs optimization and larger trials are required.
Why it matters: Provides early clinical evidence that immune modulation with a mushroom-derived extract could support natural clearance in some women. Frontiers+1

2) Bench-to-Bedside Program on AHCC and HPV

Design: Translational program (cell/animal work → pilot human studies).
Key points: AHCC appeared to modulate host immunity (e.g., interferon-β dynamics) and was explored as a supportive approach for clearing high-risk HPV from “bench to bedside.”
Why it matters: Lays out the biologic rationale and clinical pathway for testing AHCC in persistent HPV, while calling for controlled trials. Frontiers

3) Double-Blind, Placebo-Controlled Trial in Healthy Adults

Design: Randomized, double-blind, placebo-controlled.
Key points: AHCC increased dendritic cell (DC1/DC2) numbers and mixed-lymphocyte reaction versus placebo; no significant between-group differences in NK activity or cytokines were detected.
Why it matters: Suggests specific antigen-presenting cell changes in humans; mixed results underline the need for larger, targeted endpoints. PubMed

4) Immune Review: NK and T-Cell Modulation

Design: Peer-reviewed narrative review.
Key points: Across preclinical and clinical literature, AHCC has been reported to influence NK cell function and T-cell responses, mechanisms central to host defense.
Why it matters: Summarizes the broader immune-modulating profile that motivates clinical testing in infection-related contexts. PMC

5) Journal of Nutrition: Viral Challenge Model (Animals)

Design: Controlled mouse studies with influenza challenge.
Key points: AHCC supplementation enhanced NK-cell responses and improved survival metrics under viral stress.
Why it matters: Provides mechanistic/functional data that immune surveillance can be augmented in vivo, supporting human exploration. The Journal of Nutrition

6) Nutrition Research: Low-Dose, Respiratory Outcomes (Animals)

Design: Mouse studies with low-dose AHCC.
Key points: Reported improved survival, stronger NK activity, and better lung function under infectious stress.
Why it matters: Reinforces dose-response and respiratory-immune angles seen in preclinical work. ScienceDirect

7) Infection & Immunity: Stress/Genital Infection Model (Animals)

Design: Mouse stress model with genital Chlamydia exposure.
Key points: AHCC feeding restored protective immune function in stressed mice and reduced susceptibility to genital infection.
Why it matters: Highlights immune resilience under stress—relevant to persistent infections where host defenses are taxed. ASM Journals

8) Human Study on Immune & Stress Responses (Healthy Adults)

Design: Human observational/intervention work in healthy volunteers.
Key points: Data suggest maintenance or improvement of NK-cell activity alongside stress-response measures in a wellness context.
Why it matters: Extends immune-support observations into everyday settings; still requires larger controlled trials. ResearchGate